Carnosine and Autistic spectrum Disorders

Autism spectrum disorders (ASD) are neuro-developmental disorders characterized by social-interaction difficulties, communication challenges and a tendency to engage in repetitive behaviors. However, symptoms and their severity vary widely across these three core areas. Taken together, they may result in relatively mild challenges to more sever symptoms, as when repetitive behaviors and lack of spoken language interfere with everyday life.

It was pretty exciting when Dr. Michael Chez, a neurologist, published the results of treatment of autistic disorders (autism and Asperger syndrome). Since 2001, he has treated almost 1 000 autistic children with carnosine. Based on this study, Dr. Chez suggested that carnosine may improve neurological function. He found that, in 80% to 90% of cases, the condition significantly improved after only 8 weeks from starting the treatment. Doctor Chez claims that carnosine acts in the frontal parts of the brain, where its effects join the effects of the neurotransmitters acting in the deep parts of the brain. The outstanding results of this treatment were confirmed by parents of autistic children, after just one week from starting the treatment. Improvement was observed in communication, behavior and social contact. Treatment of dyslexics by doctor Chaz also showed improvement, mainly in reading skills and level of attention. In addition to reports on the treatment of 1 000 autistic children, Doctor Chez conducted the double-blind research with 31 autistic child with similar results. The double-blind study means that it wasn’t known which children received the supplement and which received the placebo. Children who received the placebo made no gains. He gave them 400 mg of pure L-carnosine per day and no side effects have been observed.

Administration of carnosine resulted in demonstrable improvements in autistic behaviors as well as increases in language comprehension that reached statistical significance. Although the mechanism of action of this dipeptide is not well understood, it is believed that it acts to modulate neuro-transmission and affect metal ion transfer of zinc and copper in the entorhinal cortex.

Karnozin Extra may enhance neurological function or act as a neuroprotective peptide.

The research, which was published in January 2007 in the journal Psychological Science, has shown that children with dyslexia cannot filter incoming information, making it difficult to create mental categories for identifying sounds of letters and words. Studies were led by neurologist Zhong-Lin Lu (University of Southern California), research associate Anne Sperling (National Health Institute), a psychologist Franklin Manis (University of Southern California) and psychologist Mark Seidenberg (University of Madison – Wisconsin).

These scientists believe that the inability of filtration of sounds from the environment may result from abnormally low level of the neurotransmitter GABA, which helps the brain to filter irrelevant information. Karnozin Extra, among other things, stimulates the production of neurotransmitters, protects the central nervous system and thus has a positive influence on dyslexia.

Parents of children with dyslexia noticed improvement in reading and a higher concentration in their children after a few weeks of using Karnozin Extra.