Carnosine and Multiple Sclerosis

Multiple sclerosis (MS) is an unpredictable, often disabling disease of the central nervous system (CNS) in which the flow of information within the CNS, and between the CNS and the periphery is disturbed. The progression, severity, and specificity of symptoms in a person suffering from MS cannot be predicted. In most people with this disease, MS is diagnosed between 20 and 50 years of age, of which affect at least two to three times more women than men.

Multiple sclerosis (MS) involves an immunologically mediated process in which there is a disturbed response of the immune system of the organism directed against the central nervous system (CNS). The exact antigen or target that activates the cells of the immune system for the attack – remains unknown, which is the reason why many experts believe that multiple sclerosis is a disease that is “immune-mediated” rather than an autoimmune.

• Within the CNS, the immune system attacks the myelin – oily substance that surrounds and covers the nerve fibres.
  • Damaged myelin forms scar tissue (sclerosis), which is why the disease got its name.
  • When any part of the myelin or nerve fibre is damaged or destroyed, the nerve impulses travelling to and from the brain and spinal cord are altered or discontinued, thereby causing a wide range of symptoms.
  • It is believed that the disease is activated in genetically predisposed individuals by combining one or more environmental factors.
  • People with MS usually suffer from one of four forms of the disease, which may be mild, moderate or severe (CIS), relapsing-remitting MS (RRMS), primary progressive MS (PPMS), and secondary progressive MS (SPMS ).

There is no cure for multiple sclerosis. Medicines used to treat MS, together with poor activity, may have side effects and most of them are difficult to tolerate.

Karnozin Extra has shown surprising and incredible results with MS patients. For example, patients taking carnosine have subjectively observed that the symptoms that had occurred before carnosine administration was withdrawn. Since MS can damage neurons in the brain and spinal cord, muscles can become weak and ineffective. Muscle spasms and cramps, or sudden uncontrolled movements, also known as spasticity, are very common in patients diagnosed with MS. It is noticeable that carnosine increases muscle strength and contraction and reduces cramps. Furthermore, the first symptom that patients mostly notice after using carnosine is the so-called “heat in the legs”. This can be explained by the effect of carnosine that acts as a neuropeptide (enhances the transmission of nerve impulses) or the removal of toxic metabolic products from cells that have suffered from oxidative stress. Also, patients notice that fatigue, tingling, dizziness, nausea, and visual problems have decreased. There are even patients diagnosed with MS several years ago who immediately started using carnosine and in which no MS symptoms have yet appeared.

Patients reported:
• Cramps are reduced by intensity and frequency until the complete disappearance of cramping
• Muscular strength increased considerably
• Improved vision
• Improved fine motoric (coordination of arm muscles, hand and arm movements)
• Increased libido
• Increased understanding of speech

• The scientists found that MS patients have lower levels of carnosine in their muscles. Even physical activity could not restore and increase carnosine levels.

https://www.msard-journal.com/article/S2211-0348(18)30058-0/fulltext 

 

• The following study involved 51 MS patients and their conditions have been assessed via standardized Modified Fatigue Impact Scale (MFIS) and SF-36 questionnaires, before and after each month of taking supplemental carnosine (Karnozin Extra). Supplementation with Karnozin Extra resulted in a significant fatigue reduction and improved health-related quality of life in patients suffering from MS, while a treatment protocol was well tolerated.

https://www.researchgate.net/publication/338180164_Medium-term_carnosine_supplementation_positively_affects_patient-reported_outcomes_in_multiple_sclerosis

 

• The pilot clinical study involving 3 MS patients receiving supplemental carnosine is registered at https://clinicaltrials.gov/ct2/show/NCT03995810?term=carnosine&draw=2&rank=1, completed and the results are available.

https://academic.oup.com/cdn/article/4/Supplement_2/1229/5845248

The MS patients underwent clinical examination (laboratory analysis, autonomous nervous system function, MRI, etc..) before and after 8 weeks of supplementation.

The summarized results are as follows:

1. Reduced fatigue
2. Improved work capacity
3. Improved autonomic nervous system function
4. Improved serum total antioxidant capacity
5. Reduced blood lactate levels (inflammation marker)
6. Increased “good” brain metabolites (choline, creatine, myo-inositol)
7. Reduced “damaging” brain metabolite – glutamate

Since Karnozin Extra has no toxic effects, it is a natural systemic supplement and does not interfere with any known multiple sclerosis therapies, it can be safely recommended as an additional therapy for the treatment of this disease.

Are all supplements based on Carnosine the same?

A patient diagnosed with MS and his experience with Karnozin Extra (English subtitle available):

Patients with MS talking about their experience with Karnozin Extra (English subtitle available):

Published: April 2018.